LASSE: abstract

Topic: Seizures and epilepsies early in life

Solomon L. Moshé

 

Department of Neuroscience, Department of Pediatrics, Laboratory of Developmental Epilepsy, Albert Einstein College of Medicine, 1410 Pelham Parkway South, Bronx, NY, USA.The Saul R. Korey Department of Neurology, the Dominick P. Purpura

 

 

The lectures and practical discussions will address issues relating to seizures and epilepsies in humans early in life. They will cover the gamut of behavioral manifestations; their etiology and prognosis and differentiate from non epileptic movement disorders. Characteristic EEG patterns will be shown that include ictal

and postictal abnormalities.

 

Additional lectures will describe animal models of seizures and epilepsies that may depict the unique features of the human seizures during the first year of life. The lectures will raise the important issues related to the emergence of these seizures and their pathophysiology. At the end the students should be able recognize human seizures and their EEG correlates; will know how to produce experimental seizures in young animals; be aware of the limitations of the models; develop an understanding as to why the immature CNS is susceptible to seizures; what are the consequences and how to look for therapeutic regimens that take into account the developmental stage of the brain as a function of gender.